Care and Feeding of BigSur

Today is maintenance day on BigSur, the CMLD-SCC NMR. I made two major upgrades:

#1) BigSur has a new workstation. I swapped the old workstation (which had a bad fan) for a brand new computer. As far as I can discern the configurations are the same, however let me know if you notice any odd behavior. The only difference you should be aware of is that you'll need to remap your network drives in order to access your data remotely. I synced the data with the old computer, so if you remap the drive you should be able to continue as if nothing changed.

#2) I swapped the probe. The old (BBO) probe could not be tuned properly on the 1H channel, leading to large(r) pulse widths, low(er) 1H signal-to-noise and less 1H decoupling bandwidth. I put a different probe (called a BBI) in the magnet. This probe will have slightly better 1H sensitivity at the cost of less 13C sensitivity. Hence, I would recommend considering sending any 13C-detected experiments to the cryoprobe via our courier service.

Justin

Happy Birthday Les Mitscher

The KU NMR lab would like to wish a very happy 80th birthday to Professor Les Mitscher. Les is a University Distinguished Professor in the Medicinal Chemistry Department in the School of Pharmacy. Les's research focuses on spectroscopy, synthesis, screening and structure determination primarily of naturally occurring antimicrobial, anticancer and antimutagenic agents, and development of combinatorial methodologies.

To honor Les's contributions there is a symposium today (I call it "LesFest"). The KU NMR Core lab is presenting a poster entitled "qNMR: absolute and relative quantitative NMR," which covers recent work we have done to establish a qNMR protocol at KU.